Evaluation of high sensitive C-reactive protein in development of CVD and stroke among T2 diabetes mellitus

For atherosclerosis, diabetes is considered as important risk factor. In diabetes mellitus patients, atherosclerotic vascular disease is most important cause of morbidity and mortality. In the pathogenesis of Cardiovascular Diseases (CVD)and stroke inflammation plays a key role. Serum concentration of CRP can increase more than 1000 times upon inflammation and with half-life of 19 h; CRP is stable marker of the inflammatory process. In the process of initiation and progression of atherothrombotic, inflammation is the central role in the triggering of CVD events. The interaction of innate immune system with atherosclerosis is established in vascular biology.

Management of Personality Disorders in the Emergency Department in Elderly

The management of patients with Personality Disorders (PD) is a problem that arises relatively frequently in Emergency Departments (ED); this could be even more problematic in geriatric patients for their particular condition and comorbidities. 

Personality disorders tend to be under diagnosed in clinical settings, and it has been well established that patients with some kind of PD, such as Borderline Personality Disorder are often difficult to treat because of the persistence and severity of their symptoms and because of the negative effects of the pathology on thetreatment relationship. Few studies have considered the prevalence of psychiatric disorders among all patients examined in an emergency service and even less evaluated the prevalence of personality disorders.

Comparison of a kanamycin versus hygromycin resistance gene in transgenic plant selection of Arabidopsis thaliana L

The neomycin phosphotransferase II (nptII) and hygromycin phosphotransferase II (hptII) genes, originally isolated from E. coli are widely used as selectable markers in transgenic research. The recovery of transgenic plants in the presence of respective selection agent has been greatly facilitated by these genes. The nptII gene confers transgenic plants resistance to the antibiotic, kanamycin, kan, and the hptII gene provides transgenic plants resistance to the antibiotic, hygromycin, hyg. 

These antibiotics normally inhibit protein synthesis in plants by binding to ribosomes. However, in the transgenic plants, the encoded enzymes, NPTII and HPTII catalyze the phosphorylation of kan and hyg respectively, once they enter into plant cells. The phosphorylated kan and hyg are inactive and therefore, unable to shut down the protein synthesis machinery in plants. This enables transgenic plants to grow in the presence of these antibiotics. Because there is no endogenous NPTII or HPTII activity in plants, these antibiotics can normally inhibit the growth of non-transgenic plants.

Journal of RNAi and Gene Silencing

The Journal will publish high-quality peer-reviewed articles addressing the biology and application of RNA interference and gene silencing in all systems. The Journal aims at providing an efficient route to fast-track publication, within 6-8 weeks of manuscript submission if accepted. Furthermore, manuscripts will be made available online in their final form generally within two weeks of acceptance.

The Journal will be primarily published online but on sufficient demand for printed version journal hard copies may also be provided to individuals and institutions.

Manuscripts in the following categories will be considered for publication: reviews and mini-reviews, research articles and short research reports, new methods and technologies, opinions on previously published literature, letters to the editor, meeting reports and commercial, patent and product news (inquiries to the Editor).

Evaluation of high sensitive C-reactive protein in development of CVD and stroke among T2 diabetes mellitus

For atherosclerosis, diabetes is considered as important risk factor. In diabetes mellitus patients, atherosclerotic vascular disease is most important cause of morbidity and mortality. In the patho genesis of Cardiovascular Diseases (CVD) and stroke inflammation plays a key role. Serum concentration of CRP can increase more than 1000 times upon inflammation and with half-life of 19 h, CRP is stable marker of the inflammatory process. In the process of initiation and progression of atherothrombotic, inflammation is the central role in the triggering of CVD events. The interaction of innate immune system with atherosclerosis is established in vascular biology. TO envisage cardiovascular risk more perfectly have led to the emergence of a novel risk factor.

Carcinogenesis from the view point of the work of the morpho functional zones and aging

The structural organization of tissue attracts great scientific interest as processes of proliferation and differentiation of cells and, therefore, the mechanisms regulating these processes are closely connected with it. Disturbance of these processes can lead to the development of a malignant tumour in the organism. From literature it is known that all the cells of the epidermal basal layer and epithelial tissue are grouped into the epidermal proliferative units (EPU). 

The central group of cells including a stem cell and peripheral cells are the part of such unit. The behaviour of a stem cell is defined by a so called niche, i.e., a cellular environment of a stem cell. For the first time the idea of existence of niches was put forward by Schofield. The author assumed that hemopoetic stem cells are surrounded by the other cells and become the fixed stem cells. During stem cell division only one remains as a mother cell and the another daughter cell is exposed to a differentiation. 

FBN1 and TGF? 1: Molecular mechanisms in the pathogenesis of thoracic aortic aneurysms and dissections

Thoracic aortic aneurysms (TAAD) develop asymptomatically until occurs aortic rupture or dissection often cause of morbidity. A high mortality is determined by TAAD and complications developing. 15,000 people die every year due to the complications of TAAD in USA. It takes 14th place according to the reasons of mortality among 55 years people and older.

The main risk factors for TAAD formation still remain under discussion. Hypertension, atherosclerosis, age, gender and eventually genetic predisposition are on the focus for the research. Only in certain cases it is caused by aortitis, atherosclerosis or inherited as a single gene mutation: in the fibrillin genes - Marfan syndrome, by inherited collagen mutations as in Ehler-Danlos syndrome, by mutations of the transforming growth factor-beta gene causing Loeys-Dietz syndrome or by actin gene mutations. Evidence has shown that FBN1 mutations may predispose TAA in the absence of phenotypic characteristics of Marfan syndrome.