FBN1 and TGFß1: Molecular mechanisms in the pathogenesis of thoracic aortic aneurysms and dissections

Thoracic aortic aneurysms (TAAD) develop asymptomatically until occurs aortic rupture or dissection often cause of morbidity. A high mortality is determined by TAAD and complications developing. 15,000 people die every year due to the complications of TAAD in USA. It takes 14th place according to the reasons of mortality among 55 years people and older.

The main risk factors for TAAD formation still remain under discussion. Hypertension, atherosclerosis, age, gender and eventually genetic predisposition are on the focus for the research. Only in certain cases it is caused by aortitis, atherosclerosis or inherited as a single gene mutation: in the fibrillin genes - Marfan syndrome, by inherited collagen mutations as in Ehler-Danlos syndrome, by mutations of the transforming growth factor-beta gene causing Loeys-Dietz syndrome or by actin gene mutations. Evidence has shown that FBN1 mutations may predispose TAA in the absence of phenotypic characteristics of Marfan syndrome.

Evaluation of high sensitive C-reactive protein in development of CVD and stroke among T2 diabetes mellitus

For atherosclerosis, diabetes is considered as important risk factor. In diabetes mellitus patients, atherosclerotic vascular disease is most important cause of morbidity and mortality. In the pathogenesis of Cardiovascular Diseases (CVD)and stroke inflammation plays a key role. Serum concentration of CRP can increase more than 1000 times upon inflammation and with half-life of 19 h; CRP is stable marker of the inflammatory process. In the process of initiation and progression of atherothrombotic, inflammation is the central role in the triggering of CVD events. The interaction of innate immune system with atherosclerosis is established in vascular biology.

Management of Personality Disorders in the Emergency Department in Elderly

The management of patients with Personality Disorders (PD) is a problem that arises relatively frequently in Emergency Departments (ED); this could be even more problematic in geriatric patients for their particular condition and comorbidities. 

Personality disorders tend to be under diagnosed in clinical settings, and it has been well established that patients with some kind of PD, such as Borderline Personality Disorder are often difficult to treat because of the persistence and severity of their symptoms and because of the negative effects of the pathology on thetreatment relationship. Few studies have considered the prevalence of psychiatric disorders among all patients examined in an emergency service and even less evaluated the prevalence of personality disorders.