Evaluation of high sensitive C-reactive protein in development of CVD and stroke among T2 diabetes mellitus

For atherosclerosis, diabetes is considered as important risk factor. In diabetes mellitus patients, atherosclerotic vascular disease is most important cause of morbidity and mortality. In the patho genesis of Cardiovascular Diseases (CVD) and stroke inflammation plays a key role. Serum concentration of CRP can increase more than 1000 times upon inflammation and with half-life of 19 h, CRP is stable marker of the inflammatory process. In the process of initiation and progression of atherothrombotic, inflammation is the central role in the triggering of CVD events. The interaction of innate immune system with atherosclerosis is established in vascular biology. TO envisage cardiovascular risk more perfectly have led to the emergence of a novel risk factor.

Carcinogenesis from the view point of the work of the morpho functional zones and aging

The structural organization of tissue attracts great scientific interest as processes of proliferation and differentiation of cells and, therefore, the mechanisms regulating these processes are closely connected with it. Disturbance of these processes can lead to the development of a malignant tumour in the organism. From literature it is known that all the cells of the epidermal basal layer and epithelial tissue are grouped into the epidermal proliferative units (EPU). 

The central group of cells including a stem cell and peripheral cells are the part of such unit. The behaviour of a stem cell is defined by a so called niche, i.e., a cellular environment of a stem cell. For the first time the idea of existence of niches was put forward by Schofield. The author assumed that hemopoetic stem cells are surrounded by the other cells and become the fixed stem cells. During stem cell division only one remains as a mother cell and the another daughter cell is exposed to a differentiation.